MuscleMeds : MethylBurn Extreme

If you are looking for an edge to get in your best shape ever and get much better results from your training and weight loss program, MethylBURN Extreme is the answer. Yes, adding this new super-pill will give you significantly better fat burning and performance in the gym. MethylBURN Extreme is designed to promote increased calorie and fat burning in an entirely new way using advanced thermogenic fat-burning hybrid technology. Find out how this scientific breakthrough will help you finally get the lean, sculpted body you’ve been working for!*

Multi-Functional Hybrid Formula Benefits:

• Maximizes Thermogenesis*
• Increases Calorie Burning*
• Increases Metabolic Rate*
• Utilizes Fat for Energy*
• Increases Strength & Endurance*
• Suppresses Appetite*

RESEARCH PROVEN Effects:

• 12 times more calories burned*
• 3 times more strength performance*
• Potent Methylated Fat-Burning Compounds*
• Fast Absorption – Sustained Delivery!*

MethylBURN Extreme’s advanced hybrid design works on multiple pathways to facilitate maximum fat-burning effects. The key to MethylBURN’s effectiveness is its unique Thermodynamic Hybrid design of synergistic clinically researched ingredients, which triggers potent thermogenesis, calorie burning, fat metabolism, satiety and enhanced muscle strength and performance.*

MethylBURN Extreme’s FastBurn Methylated Thermogenic Matrix quickly increases the release of norepinephrine to spark thermogenic fat incineration and mobilize fatty acids. This is followed by a series of synergistic fat-burning pathways via Thermogenic Sustaining Agents to further facilitate this potent fat-burning cascade. In fact, MethylBURN Extreme is so powerful, it can actually help you burn up to 12 times more calories. MethylBURN’s technologically advanced Oxcenerate catalyst enhances and prolongs the thermogenic cascade and metabolic pathway required for using fats for energy. This results in extreme fat-torching effects and can also triple your muscle strength endurance and performance. You get all this fat burning and muscle performance action in one new revolutionary super-pill!*

MethylBURN Extreme’s advanced synergistic compounds provide both fast and sustained activity to optimize fat burning, energy and power during your workouts while continuing to incinerate fat for energy after your workouts and throughout the day. No other fat burner works like MethylBURN Extreme because no other formula contains these proprietary, clinically tested compounds and advanced hybrid design.*

MuscleMeds MethylBURN Extreme – If you have the WILL we have the PILL.

MethylBURN Ingredients and Actions Overview

FastBurn Methylated Thermogenic Matrix:

Methylation

In nature, biochemicals exist in various forms, which scientists have determined display different rates of intestinal absorption and bioactivity in the body based on characteristics of their molecular design. From researching the pharmacokinetics of thousands of biochemicals, it was determined that for certain compounds, their methlyated compound versions are better absorbed and therefore have increased bioavailability, making them more bioactive in the body. Therefore, methylation is a sort of “capping” of a molecule’s reactive biochemical structure. When these reactive groups are methylated, this prevents other reactive substances from combining with them, which increases their rate of absorption. Once in the body, the methylation also protects the molecules from metabolic destruction, in particular from the liver. Once these methlyated bioactive molecules are circulated to the body’s tissues, they can go to work to perform their intended functions.*

This differential bioavailability phenomenon led MuscleMeds researchers down the road of ingredient discovery, a journey that resulted in the inclusion of methylated versions of the key ingredients that resulted in improved bioactivity.

Methyl-Synephrine (Beta-Receptor Agonist)

Methyl-Synephrine is a naturally occurring compound that research has reported can stimulate thermogensis. The Methylated Synephrine used in MethylBURN provides for increasing the stability and bioavailability of this ingredient, getting more into the body at a faster rate. Methylation provides an additional benefit from increasing the half-life once in the bloodstream, which extends its duration of action and effectiveness. Methyl-Synephrine stimulates the Thermogenic Fat-Burning cascade through two primary modes of action: 1) Exerts direct beta-receptor stimulatory action, in particular higher stimulation of the Beta-3 receptors reported to be of vital importance for maximizing the thermogenic fat-burning effect and 2) Stimulates the increase of the body’s naturally occurring thermogenic activating substances, namely, norepinephrine (noradrenaline) and adrenaline (epinephrine).*

Methyl-Beta Phenethylamine (Neurotropic Regulator and Synergist)

Methyl-Beta Phenethylamine (Methyl-Beta PEA) is a psychotropic monoamine. In the human brain, it is reported to function as a neuromodulator or neurotransmitter and elicits extreme psychoactive effects on the body while triggering body fat metabolism. Methyl-Beta PEA enters the brain and triggers a cascading release of dopamine and stimulates the mesolimbic reward pathway, causing desirable mood-elevating action, promoting euphoria, excitement and satisfaction. Methyl-Beta PEA provides additional thermogenic synergistic action through potentiating norepinephrine production. This special Methyl-Beta PEA molecular configuration increases the half-life in the body and prolongs the psychotropic and synergistic thermogenic enhancing actions. Methyl-Beta PEA is also shown to exhibit powerful appetite suppression actions.*

Methyl-Tyramine (Beta-Receptor Agonist)

Methyl-Tryamine serves multiple functions in the formula to enhance the thermogenic effect. Methyl-Tryamine is a monoamine compound, which is reported to cause the release of other monoamines/catecholamines, such as dopamine, norepinephrine and epinephrine. Methyl-Tryamine also has MAO inhibiting activity. In the MethylBURN formulation, Methyl-Tryamine acts directly and synergistically to enhance the beta-receptor stimulated thermogenesis to optimize the fat metabolizing effects. As a MAO inhibitor, this helps to reduce the MAO enzyme’s breakdown of Methyl-Beta Phenylethylamine (Methyl-Beta PEA), thereby enhancing its beneficial effects.*

Caffeine (Lipolytic Action Enhancer, Thermogenic Catalyst, Phosphodiesterase Inhibitor, Adenosine Receptor Blocker, Methyl-Beta PEA Enhancer)

Pharmaceutical quality caffeine plays a few roles in increasing fat metabolism and thermogenesis in addition to its ability to increase mental and physical performance. It is both a central nervous system and metabolic stimulant. Caffeine administration has been reported to help increase lipolysis and to promote a shift in the energy utilization of body fat. As an inhibitor of phosphodieserases, caffeine increases cAMP levels which help it function as a metabolic-supercharger. This greatly enhances and intensifies the thermogenic effects of norepinephrine and epinephrine. Furthermore, caffeine also contributes to increasing the lipolysis process, which mobilizes fats from stored body fat into the bloodstream to be used as a source of energy by muscles and other body tissues, thereby enhancing the availability of fatty acids to be used for energy production.*

Additionally, caffeine exerts effects as an antagonist of adenosine receptors. Adenosine is found in every part of the body, playing a vital role in ATP related energy metabolism and additional special functions in the brain. Some evidence indicates that the adenosine receptor system interacts with the dopamine system, which is involved in mood enhancement, pleasure and arousal. The reduction in adenosine from caffeine blocking the adenosine receptor site leads to increased activity of dopamine, enhancing the effects of Methyl-Beta PEA.*

These potent properties of MethylBURN’s pharmaceutical quality caffeine are an important adjunct to the overall formula of MethylBURN to enhance fat loss and increase exercise performance.*

AfterBurn Thermogenic Sustaining Agents

4-(4-Hydroxphenyl)butan-2-one (RK) (Norepinephrine LIpolytic Agent)

RK is a recently discovered new fat-burning compound with compelling data gathered from research conducted on RK’s thermogenic effects in animal studies. These impressive studies have led scientists to explore the potential thermogenic effects on humans. The structure of RK is similar to the structures of other thermogenic stimulating substances like capsaicin and synephrine. RK significantly increased norepinephrine induced lipolysis associated with the translocation of hormone sensitive lipase from the cytosol to lipid droplets in experimental fat cells. The researchers reported that the lipid metabolism effects of 4-(4-Hydroxphenyl)butan-2-one (RK) appear to stem from the action in altering the lipid metabolism or, more specifically, in increasing norepinephrine induced lipolysis in white adipocytes.*

Capsimax Capsaicin Fruit Extract (Metabolic Optimizer)

Capsimax (a proprietary form of capsaicin) and purified capsaicin have been subject to research studies reporting on the thermogenic enhancing benefits and role as fat loss aids. As part of a thermogenic blend containing niacin, caffeine and capsimax, an impressive preliminary research study reported a significant increase in energy production after a workout as compared to people taking a placebo. Subjects taking the exact caspimax, caffeine and niacin blend contained in MethylBURN prior to exercise experienced increased metabolism before, during and after exercise. The subjects burned up to 278 more extra calories cumulatively when compared to the placebo group. The majority of extra calorie burning was reported to occur after exercise, which is why Capsimax is a featured ingredient in the AfterBurn blend. Subjects actually burned more than 12 times more calories one hour after exercise. The researchers also reported improved exercise performance, an extra benefit for people who are serious about improving their exercise effectiveness.*

Oxcenerate (3,3′-dihydroxy-β-carotene-4,4′-dione) (Lipid Metabolizer)

In independent research studies, Oxcenerate was reported to produce important physical benefits as determined from clinical trials and laboratory supporting studies. Oxcenerate was shown to promote increased endurance, reduced muscle damage and improved lipid metabolism. Increased lipid metabolism allows for the utilization of fat rather than carbohydrate as the main source of energy during strenuous activity. This adds to the overall MethylBURN Thermogenic Fat-Metabolizing effect of using more fat for energy, while helping to spare muscle glycogen.*

The mechanism behind muscle endurance is based on several findings. Generally, Ocenerate protected the skeletal muscle from the increased damage of oxidative stress generated by physical activity. Furthermore, Oxcenerate was shown in a research study to increase the metabolism of lipids as the main source of energy production by protecting the carnitine palmitoyltransferase I (CPT I), a key enzyme involved in fatty acid transport into mitochondria. Yet another study with humans found that Ocenerate increased exercise performance, in particular increasing reps. Based on the findings of the research studies, Ocenerate has the ability to help increase fat metabolism and improve strength endurance that may lead to sports performance as well as weight loss.*

Yohimbine HCl (Alpha 2 Agonist, Methyl-Beta PEA Enhancer)

Yohimbine is an effective alpha 2-adrenoreceptor blocker, effective for increasing serum levels of norepinephrine. Yohimbine therefore promotes fat oxidation by increasing norepinephrine levels, in addition to desirable alpha-receptor antagonism (blocking) to help to maximize and sustain MethylBURN’s powerful thermogenic fat-burning effects. When the body’s thermogenic catecholamine production is increased via the direct acting beta-receptor activating MethylBURN ingredients and from the additional production of norepinephrine and adrenaline, simulation of the alpha-2 receptor occurs. This alpha-2 receptor stimulation results in down regulating the thermogenic effects. So, in addition to prolonging the fat-burning beta receptor stimulating effects by the special methylated MethylBURN ingredients, yohimbine produces additional thermogenic benefits from blocking Alpha-2 receptor activation. Yohimbine, as an Alpha-2 receptor antagonist, essentially neutralizes this negative feedback signaling and prolongs the thermogenic stimulating effects for longer periods of time. This helps to keep the fat-burning thermogenic effect going to burn more total calories and maximize the overall fat loss aid actions of the MethylBURN Beta-receptor stimulating effects.*

Bioperine Black Pepper Extract (Bioavailability enhancer)

Bioperine is a patented ingredient designed to increase the bioavailability of nutritional compounds, i.e. a bioavailability enhancer. Bioperine significantly enhances the bioavailability of supplement nutrients tested through increased intestinal absorption. Bioperine is a special standardized extract from the fruit of Piper nigrum (black pepper) or Piper longum (long pepper), and contains 95 percent of piperine. Potential mechanisms for increased nutrient bioavailability via promoting rapid absorption of nutrients include:*

• Increased Blood Supply to the GI Tract*
• Increased Emulsifying Content of the Gut*
• Increased Active Nutrient Transports*

Bioperine is also referred to as Thermonutrient, as the piperine has been reported in scientific studies to stimulate thermogenesis. Bioperine therefore helps to potentiate MethylBURN’s fast-acting absorption and powerful thermogenic enhancing effects.*

Niacin and Vitamin B12

Niacin (Synergist)

Niacin plays an essential role in energy production and was shown in a research study to boost the calorie burning rate when used in combination with other MethylBURN ingredients.*

Vitamin 12 (Synergist)

Vitamin B12 plays multiple roles in the body, including essential functioning as an enzyme needed to speed up the metabolism of fats and other energy substrates.*

MethylBurn Extreme- Clinically Tested, Scientifically Substantiated to Deliver Results

By now, you undoubtedly realize why other weight loss products you’ve used in the past haven’t been effective in helping you achieve successful fat loss. Just as you must perform multiple curling exercises to build massive biceps, it’s critical to employ multiple physiological pathways to maximize fat loss. As a result of MuscleMeds cutting edge research, MethylBURN Extreme is the key to unlock unsurpassed fat-burning potential and create a lean, ultra-ripped physique.*

MethylBURN’s powerful fat-burning action is a result of MuscleMeds’ advanced research effort to elucidate the underlying mechanisms of optimizing the Thermogenic Fat-Burning Cascade. MethylBURN Extreme is designed to strategically target the reduction of body fat while preserving muscle mass. Based on a plethora of the most recent scientific discoveries as to the vital bio-chemical mechanisms of action underlying fat metabolism, MethylBURN’s hybrid design targets multiple physiological pathways of fat-burning metabolism, utilizing potent, synergistic ingredients contained in its two proprietary compounds – FastBurn Methylated Thermogenic Matrix and AfterBurn Thermogenic Sustaining Agent. MethylBURN Extreme’s pharmaceutical hybrid design sets a new standard in fat burning supplementation with clinically tested, scientifically substantiated ingredients delivering real results.*